Richard N. Zare’s term on the Camille and Henry Dreyfus Foundation Board of Directors ended in April 2023. Dr. Zare joined the Foundation as an Advisor in February 2007. In April 2010, he was elected to the Foundation’s Board of Directors.
Dr. Zare is the Marguerite Blake Wilbur Professor in Natural Science at Stanford University. He is renowned for his research in laser chemistry, resulting in a greater understanding of chemical reactions at the molecular level. He has received 13 honorary degrees and numerous awards, such as the National Medal of Science, the Wolf Prize in Chemistry, and the Presidential Award for Excellence in Science, Mathematics, and Engineering Mentoring. Recently, he received the Benjamin Franklin Medal in Chemistry from the Franklin Institute. Dr. Zare has authored and co-authored over 1,100 publications and more than 50 patents and published four books.
H. Scott Walter, Foundation President, said: “On behalf of the Board of Directors and staff of the Dreyfus Foundation, we sincerely thank Dr. Zare for contributing his scientific expertise and enthusiasm for the chemical sciences to the Foundation’s efforts over the past 16 years.”
Dr. Zare commented: “It has been a huge honor to be a part of the Dreyfus Foundation’s Board of Directors and its outstanding work to advance the chemical sciences. I look forward to our paths crossing again in the future.”
The Camille and Henry Dreyfus Foundation has announced that Xiaowei Zhuang, Howard Hughes Medical Institute Investigator and David B. Arnold Jr. Professor of Science, Harvard University, is the recipient of the 2023 Dreyfus Prize in the Chemical Sciences. The international biennial Prize, which includes a $250,000 award, is conferred this year in Imaging in the Chemical Sciences. A public award ceremony is planned to be held at Harvard later this year.
Zhuang receives this top honor for her pivotal contributions to Imaging in the Chemical Sciences. She is recognized for pioneering work to develop groundbreaking super-resolution imaging and genome-scale imaging methods and utilizing those methods to gain important new insights about biological molecules and systems. These methods and insights have had a widespread impact in the fields of chemistry, biology, neuroscience, and medicine.
H. Scott Walter, President of the Dreyfus Foundation, remarked, “The Dreyfus Foundation is proud to recognize the numerous accomplishments of Xiaowei Zhuang in the field of imaging in the chemical sciences with the Foundation’s highest honor – the Dreyfus Prize in the Chemical Sciences.”
A groundbreaking leader in the field of super-resolution microscopy, Zhuang invented STORM (stochastic optical reconstruction microscopy), one of the earliest and most widely used super-resolution imaging methods. Overcoming the historical limitation of imaging resolution due to light diffraction, she creatively employed photoswitchable dyes and single-molecule imaging to increase the resolution of light microscopy to more than 10-times better than the diffraction limit. This methodology has been a key tool in advancing the understanding of molecular structures in cells, with her original 2006 paper alone garnering more than 8,000 scientific citations.
More recently, Zhuang invented MERFISH (multiplexed error-robust fluorescence in situ hybridization), a powerful method that took imaging to the genome scale. The technique uses error-robust barcoding, combinatorial labeling, and sequential imaging to allow for the determination of the precise copy number and spatial distribution of thousands of RNA species in individual cells, enabling single-cell transcriptome imaging. Zhuang further extended MERFISH to enable 3D-genome imaging and epigenome imaging. MERFISH transformed the studies of gene regulation in cells and the molecular and cellular architecture of biological tissues.
Zhuang has also actively employed these new methodologies to derive new insights into areas such as the cell atlas of the brain, molecular structures in neurons, and 3D organization of the genome.
“Xiaowei Zhuang’s numerous contributions to the field of imaging, most notably her invention of the STORM and MERFISH methods, have had a widespread impact on the scientific enterprise in fields from chemistry to neuroscience,” stated Matthew Tirrell, Chair of the Dreyfus Foundation Scientific Affairs Committee and Dean of the Pritzker School of Molecular Engineering at The University of Chicago.
In addition to her roles as Howard Hughes Medical Institute Investigator and the David B. Arnold Professor of Science at Harvard University, Zhuang is the Director of the Center for Advanced Imaging at Harvard. She is a co-founder of the company Vizgen, which commercialized the MERFISH technology, and is on the editorial board for both Science and Cell.
Zhuang is a member of the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society, as well as a foreign member of the Chinese Academy of Sciences and the European Molecular Biology Organization. She is also a Fellow of the National Academy of Inventors. Her many awards and honors include the Henrich Wieland Prize, J. Allyn Taylor International Prize in Medicine, the Foundation of NIH Lurie Prize in Biomedical Sciences, the Vilcek Prize in Biomedical Science, the Pearl Meister Greengard Prize, the Breakthrough Prize in Life Sciences, the Heineken Prize for Biochemistry and Biophysics, the National Academy of Sciences Award for Scientific discovery, and the MacArthur Fellowship.
Zhuang stated, “I am deeply honored to receive the 2023 Dreyfus Prize in the Chemical Sciences. I would like to thank the Camille and Henry Dreyfus Foundation for being a leading supporter of the chemical sciences community for over 75 years.”
The Dreyfus Prize in the Chemical Sciences, initiated in 2009, is conferred in a specific area of chemistry each cycle. It is the highest honor of the Camille and Henry Dreyfus Foundation.
The Camille and Henry Dreyfus Foundation is pleased to announce the selection of 18 Camille Dreyfus Teacher-Scholars for 2023. These faculty are within the first five years of their academic careers, have each created an outstanding independent body of scholarship, and are deeply committed to education. Each Camille Dreyfus Teacher-Scholar receives an unrestricted research grant of $100,000.
Vinayak Agarwal, Georgia Institute of Technology
Marine Biosynthetic Enzymology in Research and Education
Eszter Boros, Stony Brook University
Harnessing Coordination Chemistry of Non-Endogenous and Radioactive Metal Ions for Diagnosis and Therapy of Disease
Stephen Fried, Johns Hopkins University
How to Fold Every Protein – A Structural Proteomics Approach
Ariel Furst, Massachusetts Institute of Technology
Bio-Inspired Electron Transfer for Equitable Technologies
Grace Han, Brandeis University
Light-Responsive Organic Materials for a Sustainable Future
Chong Liu, University of Chicago
Designing Interfacial Ion Pathways for Critical Elements Separation
Jarad Mason, Harvard University
Manipulating Phase Transitions and Porosity in Metal-Organic Materials: From Solid Refrigerants to Porous Water
Phillip Milner, Cornell University
Simplifying Synthesis at the Interface of Organic and Materials Chemistry
Lea Nienhaus, Florida State University
Exploring Critical Parameters of Materials for High-Yield Solid-State Photon Upconversion
Jia Niu, Boston College
Precision Macromolecules for Sustainability and Biological Discoveries
Allie Obermeyer, Columbia University
Harnessing Protein Assembly for Living and Soft Materials
Lauren O’Connell, Stanford University
Predator-Prey Interactions as a Framework for Discovering New Chemical Toolkits
Zachariah Page, The University of Texas at Austin
Light as a Chemical Tool to Precisely Control Synthetic Soft Materials
Kimberly See, California Institute of Technology
Next-Generation Battery Chemistry
Christo Sevov, The Ohio State University
Battery-Inspired Strategies for Electrocatalytic Carbon-Carbon Bond Forming Reactions
Alexandra Velian, University of Washington
Molecular Approaches to Synthesize Single-Site Catalysts
Muzhou Wang, Northwestern University
New Methods Bringing Polymer Science into its Second Century
Wenjing Wang, University of Michigan
Molecular Sensors and Tools for Studying G-Protein-Coupled Receptor Signaling and Parkinson’s Diseas
We invite you to read the Camille and Henry Dreyfus Foundation 2022 Year in Review, which is now available online.
The eight-page publication spotlights the Foundation’s major accomplishments in 2022 such as the Teacher-Scholar Symposium, the 2021 Dreyfus Prize celebration, the Dreyfus/ACS Symposium on Environmental Chemistry, and new films from the Chemistry Shorts program, as well as 2023 award programs and deadlines.
Read the entire report by clicking here or on the cover image below.
The Camille and Henry Dreyfus Foundation-sponsored Chemistry ShortsTM series released its newest film, “Driving Reactions,” which explores the power of harnessing nature’s own innovations to solve problems. The film is available for immediate viewing and use in teaching free of charge on the Chemistry Shorts YouTube channel. A full lesson plan with an experiment to accompany the film is available on the Chemistry Shorts website.
Featured scientists Professor Hal Alper of the University of Texas at Austin and Nobel Laureate Professor Frances Arnold of the California Institute of Technology use directed evolution to design enzymes that work as molecular machines to solve problems in our everyday lives, helping create a more sustainable world through the power of chemistry. These new enzymes open the door of scientific progress, creating solutions for recycling waste, creating sustainable fuels, and more efficiently producing materials we use in our everyday lives. “Driving Reactions” focuses on Dr. Alper’s innovative work to design an enzyme that can degrade PET, or polyethylene terephthalate, one of the most common plastics found in water bottles and other common objects, into infinitely recyclable and reusable products.
“We have the ability to use the power of chemistry to find sustainable solutions for the future.” – Hal Alper, “Driving Reactions”
“Driving Reactions” is aimed at high school and college students and can be used as a starting point for discussions around polymer chemistry, enzyme reactions, directed evolution, DNA, and plastic recycling.
The Chemistry Shorts series spotlights the positive impact of chemistry on modern life as scientists work to solve important problems and create new opportunities that benefit humanity. See all of the films and lesson plans in this series at chemistryshorts.org and keep updated on new films and resources by following Chemistry Shorts on Twitter, Facebook, and LinkedIn.
The Chemistry Shorts series is funded in part by the Gordon and Betty Moore Foundation.